4、 Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.Yiqing Yan, Wei Jiang, Thibaud Spinetti, Aubry Tardivel, Rosa Castillo, Carole Bourquin, Greta Guarda, Zhigang Tian, Jurg Tschopp, Rongbin Zhou
Release time:2024/07/17
Hits:
- Journal:
- Immunity
- Abstract:
- Omega-3 fatty acids (ω-3 FAs) have potential anti-inflammatory activity in a variety of inflammatory human diseases, but the mechanisms remain poorly understood. Here we show that stimulation of macrophages with ω-3 FAs, including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and other family members, abolished NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1β secretion. In addition, G protein-coupled receptor 120 (GPR120) and GPR40 and their downstream scaffold protein β-arrestin-2 were shown to be involved in inflammasome inhibition induced by ω-3 FAs. Importantly, ω-3 FAs also prevented NLRP3 inflammasome-dependent inflammation and metabolic disorder in a high-fat-diet-induced type 2 diabetes model. Our results reveal a mechanism through which ω-3 FAs repress inflammation and prevent inflammation-driven diseases and suggest the potential clinical use of ω-3 FAs in gout, autoinflammatory syndromes, or other NLRP3 inflammasome-driven inflammatory diseases.
- Document Code:
- 2013-2
- Translation or Not:
- no
- Date of Publication:
- 2013/06/27
- Links to published journals:
- https://pubmed.ncbi.nlm.nih.gov/23809162/
Attachments:
- Pre One:5、 Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes. Wei Jiang, Xiaqiong Wang, Benhua Zeng, Lei Liu, Aubry Tardivel, Hong Wei, Jiahuai Han, H Robson MacDonald, Jurg Tschopp, Zhigang Tian, Rongbin Zhou
- Next One:3、 A role for mitochondria in NLRP3 inflammasome activation. R Zhou, AS Yazdi, P Menu, J Tschopp