RNA tertiary structure modeling with BRiQ potential in CASP15
发布时间：2025-08-26
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- DOI码：
- 10.1002/prot.26574
- 所属单位：
- 生物医学工程学院，苏州高等研究院
- 发表刊物：
- Proteins: Structure, Function, and Bioinformatics
- 摘要：
- We describe the modeling method for RNA tertiary structures employed by team AIchemy_RNA2 in the 15th Critical Assessment of Structure Prediction (CASP15). The method consists of the following steps. Firstly, secondary structure information was derived from various manually-verified sources. With this information, the full length RNA was fragmented into structural modules. The structures of each module were predicted and then assembled into the full structure. To reduce the searching conformational space, an RNA structure was organized into an optimal base folding tree. And to further improve the sampling efficiency, the energy surface was smoothed at high temperatures during the Monte Carlo sampling to make it easier to move across the energy barrier. The statistical potential energy function BRiQ was employed during Monte Carlo energy optimization.
- 第一作者：
- 陈珂
- 合写作者：
- 周耀旗,王晟
- 论文类型：
- 期刊论文
- 通讯作者：
- 熊鹏
- 卷号：
- 91
- 期号：
- 12
- 页面范围：
- 1771-1778
- ISSN号：
- 1097-0134
- 是否译文：
- 否
- 发表时间：
- 2025-07-01
- 收录刊物：
- SCI
