Difei Xu
- Team members Introduction:
Dr. Difei Xu serves as a Special-Term Associate Research Fellow at the Suzhou Institute for Advanced Study, University of Science and Technology of China. Her research encompasses RNA molecule design and engineering, structural and functional characterization of nucleic acid–protein interaction systems, and RNA-targeted drug screening. Dr. Xu's work centers on elucidating molecular folding&interaction mechanisms and biomacromolecular structure-function relationships, enabling structure-driven screening of RNA-targeting drugs with applications in precise drug development, biosensor design, and disease biomarker detection for biomedical advancement.
Career
2024/01-Current， Suzhou Institute for Advanced Research, USTC, Special-Term Associate Research Fellow
2022/02-2023/12，Sironax (Shanghai) Ltd.， Senior Scientist
2019/07-2021/07，The Seventh Affiliated Hospital, Sun Yat-sen University (Shenzhen)， Postdoctoral Fellow
2019/11-2020/05，Francis Crick Institute， Visiting Scholar
2018/03-2018/11，USTC， Assistant Research Fellow
Email
Main Publications
1. Difei Xu, Rongsheng Ma, Jiahai Zhang, Zhijun Liu, Bo Wu, Junhui Peng, Yanan Zhai, Qingguo Gong, Yunyu Shi, Jihui Wu, Qiang Wu, Zhiyong Zhang*, and Ke Ruan*. "Dynamic Nature of CTCF Tandem 11 Zinc Fingers in Multivalent Recognition of DNA As Revealed by NMR Spectroscopy." The Journal of Physical Chemistry Letters (2018):9(14),4020-4028.
2. Difei Xu#, Bin Li#, Jia Gao#, Zhijun Liu, Xiaogang Niu, Gilbert Nshogoza, Jiahai Zhang, Jihui Wu, Xun-Cheng Su, Wei He, Rongsheng Ma*, Daiwen Yang*, and Ke Ruan*. "Ligand Proton Pseudocontact Shifts Determined from Paramagnetic Relaxation Dispersion in the Limit of NMR Intermediate Exchange." The Journal of Physical Chemistry Letters (2018):9(12),3361-3367.